Painful blisters on the tongue and gums are the typical symptoms of hand, foot and mouth disease, with incubation period of 3-5 days, low-grade fever, general malaise, abdominal pain, etc. Painful blisters of grain to mung bean size appear on the oral cavity, pharynx, soft palate, buccal mucous membranes, tongue, and gums in 1-2 days, with a red halo around them, and they break down to become small ulcers, and they often salivate and refuse to eat due to the pain. At the same time the hands and feet also appear rash, in the hands and feet of the dorsal surface and fingers (toes) dorsal edge, around the nail, palm and plantar part, the appearance of a variable number of blisters, in addition to the hands, feet and mouth, can also be seen on the buttocks and near the anus, and occasionally can be seen in the torso and the limbs, after a few days of drying up, subside, the rash is not itchy, no pain. Individual children may have generalized papules and blisters, accompanied by aseptic meningitis, encephalitis and myocarditis. Generally well-passed, the full course of the disease is about 5-10 days, most can be self-cured, and the prognosis is good. When hand, foot and mouth disease occurs, the sick child often start with fever, its fever varies, there are also those who do not have fever, but with low fever mostly about half of the points. And often accompanied by salivation, runny nose, sore mouth, sore throat and anorexia and other symptoms. Clinical herpes of the oral cavity, hands and feet as the main features. Oral herpes is seen on the tongue, buccal mucosa, hard palate, lips, pharynx and tonsils, about 3mm in size, and quickly breaks down to form ulcers. Rash is mostly seen in the distal part of the hands and feet, fingers between the fingers, the edge of the heel and peri-nail, palms and metatarsals are also common, the lower limbs and buttocks can be densely distributed pimple-like rash, initially maculopapular, and then transformed into a herpes, round or oval, about 3-7mm such as the size of a grain of rice, smaller than the chickenpox rash, the texture of the hard, surrounded by a red halo. The number of herpes is small, only a few, more dozens. The general course of the disease is relatively light and short, more than 1 week or so healed, the rash subsides without scarring or pigmentation, such as secondary infections often make the skin damage aggravated. Hand, foot and mouth disease can be seen all year round, with more in summer and fall. The onset of the disease is characterized by fever, cough, runny nose and drooling like an upper respiratory tract infection, and some children may have nausea and vomiting. Later, oval or pike-shaped blisters appear on the backs of fingers and toes of hands and feet, with a red halo around the blisters, the liquid of the blisters is clear, and the long axis of the blisters is consistent with the skin pattern. The centers of the blisters then dimple, turn yellow, dry, and peel off (desquamation). There are also scattered, firmer, light red papules or herpes on the ends of the fingers and toes. Also, there are scattered blisters in the mouth, such as on the lips, tongue, oral mucosa, and gums, but the blisters in the mouth quickly break and form grayish-white dots or a grayish-white layer of membrane, which is surrounded by a reddish halo, and punctate or lamellar vesicles can be seen under the grayish-white membrane. Hand, foot and mouth disease is caused by viral infection, the source of infection is herpes fluid, throat secretions, fecal contamination of hands, toys, eating utensils, etc.. Its incubation period is 3-8 days. According to the epidemiological characteristics, the diagnosis is confirmed by the presence of herpes in the oral cavity, hands and feet, and the isolation and culture of the COX A19 virus in throat swabs, blood and blister fluid. Hand, foot and mouth disease should be distinguished from foot and mouth disease I. The pathogens are different. The pathogen of foot-and-mouth disease is foot-and-mouth disease virus, which is a zoonotic pathogen. Hand, foot and mouth disease is caused by several kinds of enterovirus infection. Second, the source of infection is different. Foot-and-mouth disease virus only causes even-toed hoofed (two and a half hooves) animals cattle, sheep, pigs, deer, camels and other foot-and-mouth disease, foot-and-mouth disease has become a source of infection. It is only possible to make a person sick if there is a veterinary disease first. Hand, foot and mouth disease is the source of infection of patients and intestinal virus-carrying people, belonging to human disease. Third, the transmission pathway is different. Foot-and-mouth disease is through contact with the sick animal oral cavity, hoof crown of the ulcerated spots, through the skin and mucous membrane infections; occasionally also consumed by the virus infection and not heated (pasteurization) of the milk infection. Therefore, human foot-and-mouth disease is extremely sporadic. HFMD is contracted orally through contact with a sick person, through contamination of everyday household items, eating utensils, toys, and can also be transmitted through the respiratory tract. Therefore, there can be epidemics of different scales. Fourth, the incidence of different populations. People suffering from foot-and-mouth disease decided to contact with sick animals, the age of the onset of a wide range of people, but because of the susceptibility is very low, the chance of disease is very small. Children and the elderly once the disease symptoms are more serious. Hand, foot and mouth disease is mainly young children infectious diseases, children under 3 years old accounted for the vast majority of unclear, rarely more than 5 years of age. 1983 tianjin epidemic hand, foot and mouth disease, the incidence rate of children under 3 years of age is 32.85 per thousand, 3-6 years old is 14.23 per thousand, 7-14 years old is 1.27 per thousand, 15 years of age and above 0.05 per thousand. Often in the nursery institutions appear epidemic. Fifth, the symptoms of body pieces are different. Foot-and-mouth disease, hand-foot-and-mouth disease, although the disease site in the oral cavity, fingers, toes have similarities, but the symptoms and signs are different. Foot-and-mouth disease after the onset of the disease is mainly manifested as systemic symptoms of poisoning and local herpes damage two major features. Fever, headache, general malaise, 1-2 days after the oral mucosa, tongue, fingers, toes blisters, and then 1-2 days blisters burst, forming a rotten spot, secondary infection into a pustule, and then scab, fall off, generally do not leave a scar. Duration of the disease 1-2 weeks, most of the prognosis is good, serious cases can be complicated by myocarditis. Hand, foot and mouth disease is mostly without fever or low fever, but there are symptoms of inhalation tract infection. First in the oral mucous wax appear herpes, distribution and buccal mucosa, gums, tongue side, and break into ulcers. Immediately in the fingers, feet, buttocks, knees appear papules, the next day only a small number of papules form herpes, such as mung beans, red small beans large, single sex does not fuse, containing clear liquid, the end does not break, 3-5 days of self-absorption contraction. Systemic symptoms are light, the course of the disease is about a week, the prognosis is good. Sixth, different diagnostic basis. Foot and mouth disease need to first have local livestock foot and mouth disease occurs or epidemic, and have the opportunity to contact with sick animals, or drinking sick animals contaminated and unheated milk and other infected relations. Incubation period of 2-18 a friend 3-8 days common; the onset of systemic symptoms of poisoning and local herpes, ulcer damage two characteristics.