Tongue and gum painful corn to blisters can generally be diagnosed as hand, foot and mouth disease, hand, foot and mouth disease should pay attention to differential diagnosis with foot and mouth disease. First, the pathogen is different The pathogen of foot-and-mouth disease is foot-and-mouth disease virus, which is a zoonotic pathogen. Hand, foot and mouth disease is caused by several kinds of enterovirus infection. Second, the source of infection is different foot-and-mouth disease virus only caused by even-toed hoofed (two and a half hooves) animals such as cattle, sheep, pigs, deer, camels, foot-and-mouth disease, foot-and-mouth disease has become a source of infection. It is only possible to make a person sick if there is a veterinary disease first. Hand, foot and mouth disease is the source of infection of patients and intestinal virus-carrying people, belonging to human diseases. Third, the transmission pathway is different foot-and-mouth disease is through contact with the mouth of sick animals, hoof crown of the ulcerated spots, through the skin and mucous membrane infections; occasionally also consumed by the virus infected and not heated (pasteurization) of the milk infection. Therefore, human foot-and-mouth disease is extremely sporadic. HFMD is contracted orally through contact with a sick person, through contamination of everyday household items, eating utensils, toys, and can also be transmitted through the respiratory tract. As a result, epidemics of different sizes can occur.