Plasma lipoprotein is an indicator of blood lipids, mainly synthesized in the liver, with a normal range of 0-300 mg/L. Increased plasma lipoprotein is mainly seen in atherosclerosis, cerebral infarction, cerebral atherosclerosis, and acute temporal reactions, which are clinically seen mainly in acute myocardial infarction, surgery, and acute rheumatoid arthritis. Plasma lipoproteins are now recognized as independent risk factors for atherosclerosis. It has been well established that a significant increase in plasma lipoprotein values with normal plasma cholesterol concentrations increases the risk of cardiovascular and cerebrovascular disease by more than two times that of the normal population. If both LDL and plasma lipoproteins are elevated, the risk of cardiovascular disease is more than eight times higher than in the normal population. Therefore, people with significantly elevated plasma lipoproteins should also be given high priority, especially those with elevated cholesterol, triglycerides, or LDL, and should be given timely medication to reduce the risk of cardiovascular and cerebrovascular disease.