Enlargement of submandibular gland may be caused by submandibular inflammation, salivary gland tuberculosis, IgG4-related salivary gland inflammation, etc., which need to be treated with salivary stimulating drugs, anti-tuberculosis drugs and immunomodulatory drugs respectively, as follows. 1. Hypomandibulitis: if caused by very small salivary gland stones, salivary drugs, such as vitamin C tablets, can be used to promote salivary secretion and discharge the stones. 2. Salivary gland tuberculosis: tuberculous infection of the submandibular gland leads to enlargement, which can be treated with anti-tuberculosis drugs, such as isoniazid and rifampicin. 3. IgG4-related salivary gland inflammation: belongs to autoimmune disease, can use immunomodulatory drugs, such as prednisolone, azathioprine and so on. The above drugs should be used under the guidance of a doctor, there may be other reasons for the enlargement of the submaxillary gland, it is recommended to go to the hospital in a timely manner, with the help of the doctor to clarify the cause of the disease, early targeted treatment.