Closed-cell pimples are a manifestation of acne, usually due to the sebaceous gland secretion, abnormal keratinization of follicle openings and other factors. A face full of closed-cell pimples can usually be relieved by cooperating with the doctor and choosing general treatment, topical medication, and needle clearing treatment. 1. General treatment: for the symptoms of face full of closed mouth acne, you need to keep the face clean, avoid using irritating supplies. At the same time, we should eat a reasonable diet, keep a light diet, do not eat spicy stimulating food, avoid staying up all night, is conducive to reducing sebum secretion. 2. Topical medication: After the face is full of closed mouth acne, you can use topical retinoic acid cream, adapalene, etc., so as to regulate the differentiation of the surface keratinocytes, effectively improve the keratinization of the follicular sebaceous gland ducts, and achieve the dissolution of acne and anti-inflammatory effect. 3. Needle Clearing Treatment: After local disinfection, acne needles are used to directly discharge the accumulated substances. After the diagnosis of closed mouth acne, patients should cooperate with the doctor to carry out standardized treatment to reduce the impact of the disease. All of the above medications should be used in accordance with the doctor’s instructions.