Clinical manifestations of anaphylaxis Anaphylaxis is an intense multi-organ involvement syndrome that occurs within a short period of time through the immune mechanism after the entry of certain external antigenic substances into the sensitized organism. The manifestation and degree of anaphylaxis vary greatly according to the reactivity of the organism, the amount and route of entry of the antigen. Anaphylaxis is usually sudden and severe, and can be life-threatening if not treated in time. The occurrence of anaphylaxis is related to drugs and diet, such as antibiotics, anesthetics and other drugs, milk, chocolate and other foods are easy to trigger anaphylaxis, what are the clinical manifestations of anaphylaxis? First, the symptoms of airway obstruction is the most common manifestation of this disease, and it is also the most important cause of death. Due to airway edema, increased secretions, coupled with laryngeal and/or bronchial spasm, patients experience laryngeal blockage, chest tightness, shortness of breath, wheezing, breath holding, cyanosis, so that death due to asphyxia. Second, skin and mucous membrane manifestations, often the earliest and most frequent signs of anaphylaxis, including skin flushing, itching, followed by widespread urticaria and/or angioneurotic edema; sneezing, watery nasal discharge, muffled voice, or even respiratory compromise. Third, changes in consciousness, often preceded by fear, agitation and dizziness; with the increase of cerebral hypoxia and cerebral edema, confusion or complete loss of consciousness can occur; convulsions, limb tonus and so on can also occur. Fourth, circulatory failure, the performance of the patient first palpitations, sweating, pallor, rapid and weak pulse; and then develop into cold limbs, cyanosis, blood pressure drops rapidly, pulse disappeared, and even can not measure the blood pressure, and ultimately lead to cardiac arrest. A small number of patients with original coronary atherosclerosis can be complicated by myocardial infarction. E. Skin allergies caused by eating allergic foods (fish, shrimp, crab) or insect bites are sometimes accompanied by short-term blindness. Other symptoms include irritating cough, continuous sneezing, nausea, vomiting, abdominal pain, diarrhea, and finally incontinence. Anaphylaxis can often be life-threatening, so everyone should be treated promptly if the above symptoms appear after eating food or drinking drugs. Rescue measures for anaphylaxis I. Immediately stop entering and remove the suspected allergens, or disease-causing drugs. Ligate the limb above the site of injection or bite to slow down the absorption, or the localized area of injection or sting can be closed with 0.005% epinephrine 2~5ml injection. Secondly, 0.1% epinephrine should be given immediately by subcutaneous or intramuscular injection of 0.3～0.5 ml, followed by venous puncture injection of 0.1～0.2 ml, followed by 5% dextrose drip to keep the vein free of drugs. Epinephrine can rapidly diastole bronchospasm through β-receptor effect and constrict peripheral small blood vessels through α-receptor effect. It also counteracts the release of some of the mediators of type I metaplasia, making it the drug of choice for rescue of this condition, and can be repeated several times during the course of the disease. Generally, after 1 or 2 epinephrine injections, most patients can gradually recover from shock within half an hour. On the contrary, if the shock persists without any improvement, it is a serious case, and should be injected with dexamethasone 10-20mg intravenously as early as possible, and hydrocortisone succinate 200-400mg, and can also choose a group of drugs with longer-lasting efficacy and fewer side-effects, such as norepinephrine and meso hydroxylamine, etc. At the same time, vasoactive drugs should be given, and the patient should be given with vasoactive drugs promptly. At the same time to give vasoactive drugs, and timely supplementation of blood volume, the first dose of rehydration solution 500ml can be rapidly titrated. Third, anti-allergy and its symptomatic treatment, commonly used is paracetamol 10mg or isoprinosine 25-50mg, intramuscular injection, lying down, oxygen inhalation, keep the airway open. Once anaphylaxis appears, it should be rescued immediately. Patients should also pay attention to diet during the recovery period, such as spicy stimulation and seafood and other foods should not be eaten.