Prolonged elevation of amyloid values may increase the risk of cardiovascular diseases such as atherosclerosis. Serum amyloid is an acute phase protein that is normally found in very small amounts in the body. When the body has a bacterial infection, viral infection, or an autoimmune disease, the liver synthesizes and secretes a large amount of serum amyloid into the bloodstream, resulting in an elevated level. Subsequently, serum amyloid combines with high-density lipoprotein in the blood, and high-density lipoprotein cannot transport cholesterol to the liver for metabolism, so cholesterol is deposited in the blood, which makes the blood viscous and prone to plaque formation, triggering cardiovascular diseases such as atherosclerosis. Serum amyloid is measured by enzyme immunoassay, radioimmunoassay, immunoscattering method, etc. It is a sensitive response indicator, and when elevated levels occur, it is recommended to go to the hospital for testing to clarify the cause of the disease.