Localized itching after shingles scabs come off can be treated with cold compresses, oral or intramuscular medication, and topical application of anti-itch creams. 1. Cold compress: If the itchy sensation occurs in the area after the shingles scabs come off, you can use ice to reduce the sensitivity of the skin and relieve the itching. Cold compresses can be applied for 5-10 minutes at a time and several times a day. 2. Medication: Oral antihistamines can be taken to relieve itching, such as loratadine, ebastine and other drugs; can be injected into some of the nutritive nerve drugs for treatment, such as vitamin B1. 3. Local application of ointment: the patient can apply with anti-itching effect of the ointment for treatment, such as glycerine lotion, lidocaine gel and so on. After the shingles scabs fall off, itchy, need to go to the hospital in time, follow the doctor’s instructions for medication. Try to avoid scratching with your hands to prevent scratching the skin from causing new skin destruction and combining with other bacterial, fungal and viral infections, which can cause serious consequences.