Fluconazole and Sanguine tablets at the same time is generally possible, but for safety reasons, it is recommended to stagger the time to take. Fluconazole is an antifungal drug, clinically mainly used for diseases caused by fungal infections, such as ophthalmic coccidioidomycosis, coccidioidomycosis, invasive candidiasis, such as urethritis, vaginitis, skin infections caused by fungal infections. Adverse reactions mainly include headache, dizziness, abdominal pain and nausea, and impaired liver function. Sanjin Tablet is a kind of proprietary Chinese medicine, which has the efficacy of clearing away heat and detoxification (removing heat and toxicity in the body), inducing dampness and promoting drenching and benefiting the kidneys, and it is used for the heat drenching (burning and stinging pain during urination, accompanied by frequent urination and urgency, and discomfort of pulling in the abdomen), short and reddish urination (small amount of urination, dark yellow in color), and astringent pain of gonorrhea, etc., which are caused by the dampness-heat in the lower Jiao (dampness and heat invading the intestinal tract, bladder, vagina, and the lower limbs, etc.). Adverse reactions are occasionally seen serum aminotransferase increased. The two drugs have no contraindications, can be used in combination, but there is a lack of literature on the basis of the two drugs taken together, for safety reasons, it is recommended to stagger the time to take, the specific need to use under the guidance of a doctor, to avoid their own abuse of drugs.