Defects in the skull cause the loss of the barrier that protects the brain, damaging some of the parts of the skull and thus affecting the normal activities of the body. Cranial defects that are not repaired in time can cause various symptoms that jeopardize our health and also seriously affect our appearance. Therefore, it is important to repair the skull defect as soon as possible. Cranial defect part of the patients do not want to make cranial bone repair, feel cranial defect part is not big there is no need to do, also do not go to understand what the impact of cranial bone loss, intracranial soft tissues when the loss of bone flap protection, its limitations have disappeared, cerebral venous reflux and dural sinus of the outside world pressure is reduced, the brain parenchyma can be outwardly puffed, resulting in the cerebral hemisphere of the venous reflux increase and plasma, tissue fluid and other extracellular fluid absorption This leads to an increase in venous return to the cerebral hemispheres and absorption of extracellular fluid such as plasma and tissue fluid, thus causing a decrease in the volume of brain parenchyma cells, an increase in the space inside the brain and an enlargement of the brain ventricles, which leads to hydrocephalus. The appearance of hydrocephalus brings great harm to the patient’s life and the central nervous system of the brain, and in serious cases, the patient may fall into a coma. Therefore, when the patient’s cranial defect is stabilized, cranial repair surgery must be performed. The clinical application of PEEK material is a good solution to the above problem. Based on the biology of polymer materials, PEEK material has good mechanical properties, easy plasticity, chemical stability and biocompatibility, can withstand high-temperature steam and irradiation disinfection, and radioactivity transmittance and magnetic resonance scanning does not produce artifacts, less dense, lighter weight implants are more comfortable, and will not conduct heat. This is because, as far as clinical cases are concerned, not a single case of suspected complication has been found to have arisen. Although we can’t say for sure that PEEK material is perfect, but according to the current medical methods and clinical application analysis, PEEK is the better choice for cranial bone repair surgery.