Clopidogrel and aspirin are both commonly used antiplatelet drugs in the clinic, their mechanism of action and drug characteristics are different, can not make a good or bad comparison, according to the patient’s specific situation to choose the right one. 1. Mechanism of action: Clopidogrel inhibits platelet aggregation by selectively inhibiting the binding of ADP to platelets. Aspirin inhibits platelet aggregation by reducing the production of thromboxane A2. 2.Drug characteristics: (1) Both clopidogrel and aspirin have the risk of causing bleeding, but aspirin has a higher risk of causing gastrointestinal bleeding, and there is a risk of triggering asthma in patients with asthma, chronic respiratory infections, and allergies when taking aspirin. (2) The price of aspirin is relatively low, for patients who need long-term medication less financial pressure. (3) In addition, aspirin can relieve mild to moderate pain and reduce fever, for cardiovascular disease combined with rheumatoid arthritis, osteoarthritis and other chronic pain diseases can be played at the same time the role of antiplatelet and pain. For poor economic conditions and the need for long-term medication, or patients with chronic pain, you can choose aspirin, while patients who can not tolerate the gastrointestinal side effects of aspirin, it is recommended to choose clopidogrel. During the medication, pay attention to monitor bleeding and other adverse reactions, if any discomfort, promptly go to the hospital.