The generic name of Nosintrol is sacubitril valsartan sodium tablets, which can reduce the chance of cardiovascular death and alleviate the symptoms associated with heart failure, and can be used in adult patients with chronic heart failure with NYHA classification II-IV and LVEF ≤ 40%. Adverse reactions such as hypotension, hyperkalemia, angioedema, and renal impairment may occur after administration. Because of the possibility of hyperkalemia, regular monitoring of blood potassium levels and timely treatment are required when using the drug. Combination with an ACE inhibitor (ACEI) increases the risk of angioedema, so the drug must be taken only 36 hours after discontinuing ACEI therapy. In addition, it can interact with drugs such as aliskiren, angiotensin II receptor antagonists (ARBs), sildenafil, etc., so you should consult a medical professional when using it. It is contraindicated in the following conditions: severe hepatic impairment of Child-Pugh class C; hypersensitivity to the drug; mid- to late-term pregnancy; type 2 diabetes mellitus patients taking aliskiren; taking an ACEI; angioedema associated with previous treatment with an ACEI or ARB; idiopathic or hereditary angioedema; biliary cirrhosis, cholestasis. If you need to use the drug patients, please under the guidance of a doctor to strictly follow the medical advice to take medication, do not self-medication.