Pain in the middle of the stomach can be caused by cold, gastroenteritis, pancreatitis and other causes. It can be relieved by taking oral probiotics, antibiotics, neurotransmitters, proton pump inhibitors and other drugs. 1. Cold: If the pain in the middle of the stomach is caused by cold, you need to pay attention to keep warm and avoid getting cold again. You need to pay attention to keep warm to avoid getting cold again, and you can apply hot compresses to the abdomen to prevent further spasms of the intestines from aggravating the pain. If accompanied by nausea, vomiting, intestinal flora disorders and other uncomfortable symptoms, you can take probiotics, such as bifidobacterium tetragonum tablets, lactobacillus tablets and so on. 2. Gastroenteritis: If it is a bacterial infection gastroenteritis resulting in a vague pain in the middle of the stomach. It can be treated by antibiotics such as ciprofloxacin hydrochloride tablets and levofloxacin tablets, and can also be treated with antispasmodics such as neurotransmitters such as atropine sulfate. At the same time, patients can also take montelukast powder and other intestinal mucosa protection preparations. 3. Pancreatitis: When the disease is mild, it can also be manifested as a vague pain in the middle of the stomach, which may be accompanied by fever and other symptoms. The patient is fasting within 48 hours, for the phenomenon of infection, can use cefoperazone sulbactam, metronidazole and other antibiotic treatment. It is also treated with omeprazole enteric-coated tablets and octreotide. Patients with pain in the middle of the stomach should go to the regular hospital in time, identify the cause of the disease, take targeted drugs under the guidance of a professional doctor, and take them in strict compliance with the doctor’s instructions.