Tibolone is used clinically to relieve clinical symptoms associated with estrogen deficiency due to menopause or surgery and is an estrogen replacement therapy drug. The occurrence of weight gain with Tibolone may be associated with an increase in estrogen. Some people may experience weight gain after estrogen use. One reason is that estrogen promotes the transfer of body fluids to the tissue spaces and the reabsorption of water and sodium in the renal tubules, which leads to sodium and water retention, and therefore results in weight gain after the use of Tibolone. Another reason is that after the increase of estrogen, the effect of androgen is relatively weakened. This leads to the accumulation of subcutaneous fat in the body and the slowing down of muscle production, which results in weight gain after the use of Tibolone. If you feel unwell during the use of Tibolone, it is recommended that you go to the hospital in time for consultation and use the medicine under the guidance of your doctor, do not stop or reduce the medicine without authorization, so as to avoid adverse consequences.