Psoriasis is a common chronic inflammatory skin disease, which can be accompanied by multi-system damage. Clinical classification mainly includes common type, pustular type, arthropathy type and erythroderma type, and different types have their own clinical performance characteristics. The most common type is the common type, which is mainly characterized by limited or generalized erythema, papules, plaques, covered with silvery-white scales, accompanied by varying degrees of itching and dryness. It is distributed in the head, face, trunk and limbs, but also in the folds, mucous membranes and finger (toe) nails. The pathologic changes in psoriasis vulgaris are hyperkeratosis and hyperkeratosis of the epidermis. Munro microabscesses can be seen, with a marked reduction or disappearance of the granular layer, thickening of the stratum spinosum, extension of the epidermal prominence, which may coincide with neighboring epidermal prominences, and extension of the dermal papillae in the form of a pestle and mortar, with a thinning of the spinous layer above it. The capillaries in the papillae are dilated and congested. Lymphocytes, neutrophilic leukocytes and other infiltration can be seen in the surrounding area. At present, the etiology and pathogenesis of psoriasis are not completely clear, and it may be a combination of genetic factors, microbial infections, immunologic factors, endocrine factors, neuropsychiatric factors, and skin barrier destruction. The principle of psoriasis treatment is to improve the patient’s uncomfortable symptoms, improve the quality of life and avoid systemic damage. Regarding the treatment of psoriasis, there are different treatment methods for different types, and the commonly used methods include Chinese and western medicine medication (topical medication, systemic medication), physical therapy, and biological agents. For common type psoriasis, topical drugs have a pivotal position. In recent years, many scholars have found that compound clobetasol propionate ointment (Jin Nuer) combined with other methods, the treatment of psoriasis of common type has achieved satisfactory efficacy, and few adverse reactions. Jin Nuer is a domestic topical compound preparation, the composition of clobetasol propionate and all-trans retinoic acid, the appearance of the yellow ointment with greasy base, the indications for keratotic inflammatory skin diseases. Clobetasol propionate is a potent hormone, which can target the immune factors in the pathogenesis, inhibit the proliferation of epidermal keratinocytes and T-cells, and inhibit the aggregation of leukocytes in the lesions, so as to achieve the effect of inhibiting inflammation; all-trans retinoic acid can promote the normal differentiation of keratinocytes in the skin, and at the same time inhibit the excessive proliferation of keratinocytes and the aggregation of leukocytes, and the two groups of components can play a synergistic role in targeting psoriasis. synergistic effect, targeting all aspects of the pathogenesis of psoriasis, quickly reducing patients’ itching symptoms, improving the erythema and scaling of skin lesions, and improving patients’ quality of life. All-trans retinoic acid may cause skin irritation symptoms, such as erythema, flaking, dryness, itching, etc., but combined with clobetasol propionate, it can significantly reduce the irritation reaction; long-term topical clobetasol propionate can cause skin atrophy, and combined with all-trans retinoic acid, it can significantly prevent or reverse skin atrophy. The combination of the two drugs can reduce local adverse reactions. Of course, we also need to combine other methods at the same time, such as narrow-wave ultraviolet light, the use of skin barrier repair agents and so on. Ginnul is used twice a day, usually for 3 to 4 weeks. Contraindications associated with Jinnuel: allergic to any component of the product; or to the product occurs more than mild irritation, the process of medication does not alleviate, can not tolerate, have a negative impact on the condition of the person. Precautions: should not be used for a long time and in large doses, should not be used in the areas with significant inflammation, erosion or infection, so as not to aggravate the infection or increase the absorption; women of childbearing age should not be impregnated during the use of the drug, and it is recommended to suspend the use of the drug during the breastfeeding period; it is not suitable for use by infants and children; room temperature, protected from light, and stored in airtight. There are many kinds of drugs for psoriasis treatment, but they have their own shortcomings and limitations. Since the development of psoriasis is related to many factors and the pathological mechanism is complicated, the treatment of psoriasis needs to be based on the condition of individualized principles of combined, alternating and sequential treatment, so as to minimize the incidence of adverse reactions and improve the clinical therapeutic effect. With the deepening of psoriasis research, it is expected that there will be efficient, safe and new treatment means to relieve the pain for the majority of psoriasis patients.