Hidden pain in the middle of both chests is usually referred to as sternal pain. Treatments for sternal pain include physical therapy, medication, and surgery. Sternum pain may be caused by sternum fracture, repeated strenuous chest exercise, gastroesophageal reflux disease, angina pectoris, costochondritis, leukemia and other diseases, with different causes and different treatment methods. 1. Physiotherapy: When the pain is mild, you can take a comfortable sitting or lying position and rest properly under the guidance of doctor. If it is caused by sports, trauma, sternal soft tissue contusion can be cold compress. 2. Medication (1) If the sternal pain is caused by gastroesophageal reflux disease (GERD), proton pump inhibitors (PPI) such as omeprazole are often used to inhibit acidity, and pro-gastrointestinal dynamics drugs such as domperidone can also be used to improve esophageal peristalsis and promote gastric emptying. (2) If the sternal pain is caused by angina pectoris, mild cases are usually relieved gradually after resting, while more serious patients can take drugs to lower blood pressure, heart rate, and dilate coronary arteries, such as nitroglycerin, nifedipine, metoprolol, and so on. (3) If the bone infiltration is caused by leukemia, patients should consult hematology department in time and follow the doctor’s prescription for treatment. 3. Surgical treatment: If sternal fracture, tumor or severe stenosis of coronary artery is ineffective in medical treatment, surgery can be performed according to the patient’s condition if there is no contraindication for surgery. Sternal pain should be treated as early as possible in the hospital, and the treatment should be standardized according to the doctor’s prescription.