Skull defect sounds scary, after all, it is not good to have a piece of the head missing, not to mention the aesthetic impact, but also the health damage. Because the skull is the external protective barrier of the brain, only when the skull is intact can the brain tissue be prevented from being attacked by the outside world. Therefore, when you encounter the problem of skull defect, what you should do is to go to the hospital for skull repair surgery in time. Cranial repair is a classic neurosurgical procedure that has been available since the early days and has become technically mature. Patients who are troubled by cranial defects need to go to a regular hospital and let an experienced and skilled specialist arrange the surgery for them. Can skull repair achieve the original appearance and will it affect the aesthetics? Whether skull repair can achieve good results is not only related to the choice of repair materials, but also related to the surgeon’s technique. At present, most hospitals use titanium mesh material for skull repair surgery. Compared with other materials in earlier times, titanium mesh material is an improvement, but there are still some unavoidable problems. For example, the possibility of postoperative rejection, susceptibility to infection, postoperative patient sensitivity to hot and cold environments, and the risk of material exposure. In order to remedy these shortcomings, a new type of PEEK material has emerged, which is comparable to autologous cranial bone in all its properties and can be customized to the shape of the patient’s defective bone window, highly restoring the skull shape, with ideal postoperative recovery and natural-looking results. Our team is currently using PEEK material to perform surgeries for patients, and we have also made technical innovations and optimized the design of the material, introducing the concept of aesthetic plastic surgery, truly achieving the organic unity of structural restoration, functional perfection, and aesthetic appearance.