The formation of nasopharyngeal cancer takes years or even decades. Since the clinical location of nasopharynx is relatively hidden, it is very easy to miss or misdiagnose the disease, and detailed medical history is very important. If a patient presents with unexplained blood in aspirated snot, unilateral nasal congestion, tinnitus, ear occlusion, hearing loss, headache, diplopia, or swollen lymph nodes in the deep upper neck, nasal endoscopy should be performed as early as possible, along with nasopharyngeal biopsy, and necessary tests such as EBV serology and imaging can also be performed to clarify the diagnosis. It must be noted that the primary cancer focus in nasopharynx may invade into the skull without affecting the appearance of nasal mucosa, and a negative first biopsy of nasopharynx or normal appearance of nasopharyngeal mucosa does not exclude nasopharyngeal cancer. For patients with suspected nasopharyngeal cancer, close follow-up should be paid attention to, and nasopharyngeal biopsy should be repeatedly performed several times if necessary, so as to achieve early detection, early diagnosis and early treatment.