Chronic wandering annular erythema may be SLE, rheumatic fever, tick bite, which can be treated with non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, glucocorticosteroids, etc. under doctor’s supervision. 1. Systemic lupus erythematosus: Non-steroidal anti-inflammatory drugs such as indomethacin and acetaminophen can be used to control inflammation and relieve symptoms. Glucocorticosteroids such as prednisone acetate tablets and dexamethasone can be used for treatment. 2. Rheumatic fever: Rheumatic fever is caused by type B hemolytic streptococcal infection, in order to prevent further development of the disease, antibiotics such as penicillin, erythromycin, amoxicillin, etc. for treatment. 3. Tick bite: do not easily pull out the body of the insect, may be left behind the mouthpiece, you can promptly seek medical treatment under the guidance of a doctor, the drug can take doxycycline and so on. All kinds of drugs need to follow the doctor’s instructions, under the guidance of the doctor to use.