The correct term for large bubbles is blisters, and large blisters at the base of the tongue may be caused by diseases such as pemphigus and pemphigoid, as follows. 1. pemphigus: it is a kind of serious, chronic autoimmune maculopapular disease of the skin and mucous membrane, blister blisters have thin wall, easy to break, and irregular vesicle surface remains after breaking. Rub the normal-looking mucosa with a cotton swab, and blood blisters or blisters may appear on the mucosal surface. 2. Pemphigus-like: it is an autoimmune disease clinically characterized by mucosal tension blisters and vesicles. The blister fluid may be clear or blood blisters, the blister wall is thicker, and after rupture, the blister wall may be left, and smooth red vesicles can be seen after removing them. There may be other reasons for the large blisters at the base of the tongue, it is recommended to go to the hospital in time, to clarify the cause of the disease and then targeted treatment.