Due to individual differences, there is no such thing as the best, fastest, or most effective treatment for gray nails; rather, the best option is to choose the one that is appropriate for you based on the type of infection. Commonly used treatments include topical medication, systemic medication, and non-pharmacological treatments. 1. Topical medication: commonly used for white superficial and distal lateral subnail damage. The sick nail can be removed as much as possible with a knife or nail file, and then topical 30% glacial acetic acid solution or 3%-5% tincture of iodine, twice a day, until the new nail grows out; 40% of the urea ointment can be used to seal the package to make the diseased nail soften and peel off, and then topical antifungal agents such as cyclopiazole, amorphophallus coating and so on. 2. Systemic drug therapy: Itraconazole intermittent shock therapy, nails need 2-3 courses, toenails need 3-4 courses. Terbinafine is taken continuously for 6-8 weeks for nails and 12-16 weeks for toenails. Combination therapy with topical medications may improve efficacy. These two drugs can cause liver and kidney function damage, need to follow the doctor’s instructions for medication and regular testing of liver and kidney function. 3. Non-pharmacological treatments: These include nail extraction or nail removal, laser therapy and photodynamic therapy, which are rarely used nowadays and are only used as adjunctive treatments to pharmacological treatments. Because the drug is not easy to enter the nail plate and nail growth is slow, so the treatment is more difficult, the key is to adhere to the medication, so patients with gray nails are recommended to early detection and early treatment, the effect is better.