The reason for 12 chemotherapy treatments after surgery for bowel cancer may be that the cancer recurs and metastasizes more quickly, and it is difficult to bring the growth, metastasis and spread of the cancer cells under control with a short course of chemotherapy. It may also be the normal number of times the FOLFOX regimen is used. Bowel cancer is one of the more common malignant tumors in clinical practice, and surgery combined with chemotherapy is also an important way of treating this disease. Most of the adjuvant chemotherapy performed is 6 to 8 sessions. For patients with larger lesions, whose resection may be incomplete or who have recurrence and distant metastasis, the duration of chemotherapy may need to be prolonged, especially if distant metastasis occurs, and longer cycles of chemotherapy are needed to control the progression of the disease and prolong the survival period. In addition, advanced colon cancer usually needs to be treated with FOLFOX regimen, which is a more classic chemotherapy regimen for colon cancer, which can prolong the life of patients to a certain extent and improve their quality of life, while FOLFOX regimen usually requires chemotherapy once every 2 weeks, and it may also require about half a year’s worth of chemotherapy, with a total of about 12 times. Therefore, patients should strictly follow the doctor’s instructions for chemotherapy, and after the treatment is completed, they should also have regular follow-up visits to monitor the changes in their condition.