Numbness from the calves to the soles of the feet is a sign of peripheral nerve injury, which is common in various types of peripheral nerve disease, such as polypoidal peripheral neuropathy, diabetic peripheral neuropathy, traumatic mononeuropathy, and nonspecific ischemic and hypoxic peripheral neuropathy in the elderly. In this case, it is recommended that the patient improve the nerve conduction velocity and electromyography of both lower limbs to clarify which nerve is injured and the extent of the injury. Then, the etiological examination, first of all, should improve the blood sugar, blood lipid, blood rheology, followed by the vascular ultrasound of both lower limbs, and immunity ten, blood sedimentation, ANA16, ANCA and other rheumatism and immunity related indexes. If the above examinations reveal a clear cause, further treatment will be carried out according to the cause. For example, if it is related to diabetes mellitus, we should actively control blood glucose; if it is related to lower limb vascular occlusion, we should consider putting stent or taking atorvastatin for a long time.