Possibly, long-term use of statins such as simvastatin and atorvastatin can produce a range of adverse effects, including rhabdomyolysis and myalgia, hence the sore buttocks. Statins such as simvastatin and atorvastatin are lipid-lowering drugs that work primarily by inhibiting HMG-CoA reductase, thereby lowering cholesterol and lipid concentrations. Regardless of the type of statin, the adverse effects are generally the same. These include fever, abdominal discomfort, gastrointestinal distention, cholestasis, rhabdomyolysis, arthralgia, and liver function abnormalities, so for some people it is possible to have a sore butt. The use of the drug should be prohibited for pregnant and lactating women, abnormal liver function, allergy to statin components. Statin drugs should be standardized under the guidance of a doctor, not blindly take the drug, during the drug should be light, low-salt, low-fat diet, regular recheck of liver and kidney function, and monitor changes in blood lipids. It is recommended that if there is corresponding discomfort, it is recommended to consult a doctor in time to avoid delaying the condition.