Lumbar disc herniation is a common and frequent disease. In recent years, the application of minimally invasive techniques for the treatment of lumbar disc herniation has developed rapidly and achieved certain successes, among which ozone intradiscal injection is favored for its safety, small trauma and stable efficacy. In our hospital, intra-disc ozone injection under CT guidance has been used for the treatment of disc herniation and has achieved better efficacy, which is reported as follows. 1. Object and method 1.1 Object 32 cases were treated in our outpatient clinic, of which 25 were male and 7 were female, aged 18-64 years, average 41 years, with a duration of 0.5-20 years and poor results by conservative treatment. There were 29 cases of low back pain with lower limb radiating pain, 8 cases of low back pain with hip discomfort, 21 cases of straight leg raising test; 21 cases of central protrusion type, 5 cases of lateral protrusion type, and 6 cases of limited disc bulge. The indications for ozone intradiscal injection were: CT or MRI confirmed the diagnosis of disc herniation or limited bulge and the clinical symptoms were consistent with the imaging diagnosis, and the symptoms were mainly low back pain without obvious nerve root compression symptoms. Contraindications to ozone intradiscal injection include: severe calcification of the herniated disc, severe narrowing of the intervertebral space and spinal canal, rupture of the annulus fibrosus and posterior longitudinal ligament, prolapse of the nucleus pulposus into the spinal canal, and slippage of the vertebral body. 1.2 Methods Patients were placed in the prone position, and CT scans were performed to determine the morphological type of the herniated disc. The CT positioning system was used to select and measure the puncture point, the puncture angle and depth, and the patient was routinely sterilized, lidocaine was used for local anesthesia, and a lateral-posterior puncture route through the “safety triangle” or/and a paramedian puncture route was used to allow the tip of the puncture needle to reach the herniated disc and the disc, and then a disposable 5 mL sterile syringe was used to extract a 50 μg/m concentration from the ozone generator. 10-15 mL of medical ozone with a concentration of 50 μg/mL was rapidly injected into the disc, and the needle was withdrawn to the vicinity of the intervertebral foramen, then 10 mL of ozone was injected into the paracentral space, and in patients with multiple disc lesions, ozone was injected into each lesioned disc. 1.3 Efficacy evaluation criteria The Macnab method was used to evaluate the clinical effect of ozone treatment. Excellent:disappearance of symptoms, no motor dysfunction, return to normal work and life, no signs of nerve root injury. Good: occasional low back and sciatica pain, no restriction of occupational activities. Poor:No significant improvement of symptoms, limited physical activity, no work ability, still have signs of nerve root injury. 2, results The success rate of CT-guided intervertebral disc puncture in this group was 100%, and all of them could be clearly ozone injected into the treated intervertebral disc. CT scan after injection showed that the distribution of ozone in the intervertebral disc was: eccentric or scattered sporadic punctiform distribution, central large lysis distribution, diffuse large arc-shaped distribution, and arc-shaped fissure-like distribution at the edge. In this group, after 0.5-1 year follow-up, 10 cases were excellent, 19 cases were good, and 3 cases were poor, and there were no complications such as allergic reaction, infection, or nerve damage. 3.Discussion Lumbar disc herniation is a common clinical disease that seriously affects people’s work and life, and traditional surgical treatment methods are traumatic and patients are unwilling to accept them. Ozone, as a strong oxidizing agent, can dissolve the proteoglycans in the nucleus pulposus and make the nucleus pulposus shrink and consolidate, so as to achieve the purpose of mechanical decompression. Ozone also has anti-inflammatory, analgesic and nerve root edema elimination effects. It dilates blood vessels by antagonizing the release of immune factors in the inflammatory response, thus achieving inflammation absorption; it also produces analgesic effects by inhibiting prostaglandin synthesis, bradykinin and the release of pain-causing substances. Ozone therapy operates without chemical and thermal damage and therefore does not damage nerve tissue. When it acts on nerve roots, it has an excellent anti-inflammatory effect, and it is itself an antiseptic. Its application minimizes the chance of infection in the spinal canal and does not lead to significant complications, which is one of the most remarkable features of ozone therapy. Because the puncture needle used is small and causes few complications, it is effective in elderly patients with significant disc degeneration, slightly stenosed discs and patients with combined disc bulges. Foreign literature reports that the efficiency of ozone treatment for lumbar disc herniation ranges from 68% to 79%, which indicates that the efficacy of ozone injection for lumbar disc herniation is certain. Secondly, it is worth promoting because of simple operation, high surgical safety, low patient pain and obvious efficacy, which greatly reduces the cost of medical treatment for patients. Patients with obvious spinal stenosis or lateral saphenous fossa stenosis, osteophytes, hypertrophy of the ligamentum flavum, and calcification of the nucleus pulposus are not suitable for ozone treatment.