Paroxetine hydrochloride should not be mixed with methylthiopyridazine and monoamine oxidase inhibitors. 1. Methylthiopyridazine: like other drugs that inhibit hepatic cytochrome P450 isozymes, it can easily lead to increased plasma concentrations of methylthiopyridazine, which is detrimental to the body if the two drugs are combined at the same time. 2. Monoamine oxidase inhibitors: within two weeks of the end of the drug, do not take monoamine oxidase preparations, to avoid drug-drug interactions. Paroxetine hydrochloride can be used under the direction of a doctor, and should not be taken on its own. When taking the drug, pay attention to the drug components of the allergy is prohibited, do not later there may be adverse reactions, such as loss of appetite, drowsiness, insomnia, euphoria, etc., if the adverse reaction is obvious need to stop the drug.