There is no fastest way to reduce the swelling of the knuckles. The causes of knuckle swelling include localized compression or arthritis, etc., which need to be treated according to the specific causes. 1. Compression: when the local joints and muscles in a long-term state of compression and cause local blood or fluid circulation is not good, it may cause joint swelling, generally does not cause physical injury, but there may be joint paralysis or activity disorders and other discomforts, so you can through the massage or local hot compresses to effectively improve the body fluids and blood circulation, so as to play the effect of swelling. 2. Arthritis: When there is obvious inflammation of the finger joints, swelling of the joints and their surrounding tissues will occur. For joint swelling caused by joint inflammation, you need to choose to take non-steroidal anti-inflammatory drugs under the guidance of a doctor to relieve the symptoms, commonly used are meloxicam tablets, diclofenac tablets and so on. There are many causes of swollen knuckles, and it is recommended that patients with swollen knuckles go to the hospital in a timely manner to have the cause clarified and standardized treatment under the guidance of the doctor.