Small intestinal mesenchymal tumor is a kind of smooth muscle tumor that occurs in the muscular layer of the gastrointestinal tract and is also a kind of malignant tumor of the gastrointestinal tract. For its treatment, it can be based on its growth and spread from the following aspects: 1. without metastasis, the initial small intestinal mesenchymal tumor without infiltration is usually treated by surgery, and mainly by focal resection, because it has the risk of recurrence, it should pay attention to regular review after surgery. 2. with metastasis, if there is infiltration of surrounding organs, but it does not invade the blood system, it can be treated by joint resection of surrounding organs. resection, postoperative review should also be done mainly at regular intervals. 3. For recurrent lesions, for most surgically unresectable or recurrent mesenchymal tumors, chemotherapy with molecularly targeted drugs can be taken.