The difference between bipolar disorder and depression in the clinic are: first, the form of its onset is different. Bipolar disorder is also called two-way affective disorder in the clinic, and its main clinical manifestation is mania or (and) depression alternating or mixed episodes. Depressed patients in the clinic will not appear mania, hypomania and other related content, depression is mainly based on the performance of depression. Second, the way of treatment is different. For patients with bipolar disorder, in the process of clinical treatment, the main application is emotional stabilizers and antipsychotic drugs for treatment. In the process of treatment, under normal circumstances, it is not recommended to apply antidepressant drugs. If the application of antidepressant drugs should pay attention to the monitoring process, to prevent the rapid cycling disorder caused by antidepressant drugs. The treatment of depression, in the clinic is mainly based on antidepressant drugs, the main application is selective 5-hydroxytryptamine reuptake inhibitors. Third, the prognosis for the two diseases is different. For patients with bipolar disorder, its prognosis is worse than that of patients with depression. In the treatment process, bipolar patients are often easy to turn to each other, so the dose of drug therapy, treatment is different from the treatment of depression. The treatment of depression in the clinic, the cure rate is relatively high, if after standardized, scientific treatment is often able to achieve a cure.