Once the diagnosis of atypical pertussis is confirmed, isolation and aggressive medication are recommended. Pertussis is a respiratory infection caused by the bacterium Bordetella pertussis, and some patients have a less typical clinical presentation, called atypical pertussis. Atypical pertussis is characterized by a low incidence of spasmodic coughing, mild coughing symptoms, and a shorter duration of coughing compared to common pertussis. The main symptom is a paroxysmal dry cough, which lasts for about 2-3 weeks, with frequent coughing at night, but with little sputum. Systemic symptoms are mild, with no significant fever or malaise. Atypical pertussis is also contagious, after a clear diagnosis of isolation treatment, mainly antibiotic medication, while symptomatic medication to relieve the symptoms of dry cough. Antibiotics preferred macrolides, such as azithromycin, clarithromycin, etc., if necessary, can be paired with ampicillin, amikacin and other drugs combined antibacterial; can also be selected through the drug sensitivity test sensitive antibiotic use. Symptomatic use of cough medication, such as centralized cough suppressant dextromethorphan. During the use of drugs may cause digestive discomfort, take after meals to reduce adverse reactions, allergic to drug components, pregnant women, infants and young children are prohibited, liver and kidney insufficiency under the guidance of a doctor to use with caution. Atypical whooping cough after active antimicrobial treatment for 1 week will greatly reduce the infectiousness, it is recommended to follow the doctor’s instructions to take the drug, the condition is getting worse as soon as possible to go to the hospital. The above drugs should be used under the supervision of a physician.