Whether or not pearly penile papules will grow back after laser treatment needs to be determined on an individual basis; some patients may or may not grow back. Penile pearly papules are a benign lesion with an unknown cause. It may reappear if you do not take good care of it after laser treatment. After laser treatment, you can use povidone-iodine to prevent infection under the guidance of the doctor, and also need to pay attention to personal hygiene, to keep the local clean and dry.