Glimepiride is a long-acting hypoglycemic drug, which can be taken once a day as prescribed by the doctor. Glimepiride belongs to sulfonylurea hypoglycemic drugs, on the one hand, by stimulating insulin secretion to reduce blood glucose, on the other hand, it can increase insulin sensitivity and reduce insulin dosage. It has a long half-life, once a day can control blood glucose throughout the day, twice a day may lead to hypoglycemia. Taking glimepiride requires careful monitoring of blood glucose, as it stimulates insulin secretion, so it may lead to hypoglycemia. The starting dose should be started with a small dose and gradually increased. If the use of insulin based on the combination of glimepiride more attention should be paid to monitoring blood glucose, to prevent hypoglycemia, blood glucose is low, need to consult a doctor in a timely manner, under the guidance of the doctor reasonable application of insulin. In short, the use of the drug, should be under the guidance of a doctor.