The causes of knee joint effusion are complicated, some causes such as degenerative osteoarthritis can be treated with creams, pain can be treated with pain relieving creams such as flurbiprofen babu cream, blood activating and blood stasis relieving ones such as bone pain cream, pain relieving creams, etc. If the local pain is obvious, you can apply etofenacin gel and other drugs before using the cream. If it is gout effusion, you can choose active pain relief cream, if it is rheumatoid arthritis caused by knee effusion, you can use rheumatic pain relief cream. Before using the cream, clean the area, use it for no more than 12 hours a day, and pay attention to any itching and rash and other allergic phenomena during use. If it is septic arthritis effusion, it is not suitable to choose the cream treatment, need active antibiotics such as levofloxacin and other anti-inflammatory, if necessary arthroscopic surgery.