Folic acid genetic test high risk at 13 weeks of pregnancy should increase the supplemental dose of folic acid in a timely manner, so as to play a role in the prevention of fetal malformation. The 13th week of pregnancy is still in the critical period of fetal growth and development, folic acid gene test high-risk indicates that the pregnant woman’s body folic acid metabolism and utilization of obstacles, so the routine folic acid supplementation, the pregnant woman’s body folic acid level can not play an effective role in preventing fetal neural tube malformations, at this time you need to increase the dose of folic acid supplementation in a timely manner to increase the pregnant woman’s body folic acid level, to play a preventive role. It should be noted that pregnant women should be regular obstetric examination, folic acid supplementation needs to be carried out under the guidance of a professional physician, not blindly increase the dose, so as not to take improper, resulting in adverse consequences.