Abdominal smooth muscle sarcoma is mainly treated by surgery, after which appropriate chemotherapy, radiotherapy, biotherapy, traditional Chinese medicine and so on can be selected according to the specific type of pathology. Abdominal smooth muscle sarcoma belongs to the tumor with high malignancy degree and may appear distant metastasis earlier, so the early surgical treatment after discovery includes resection of the tumor as well as the surrounding tissues infiltrated by the tumor, and lymphatic cleansing can be avoided due to the relatively low lymphatic metastasis. After surgery, the resected tissues will be sent for pathological examination, and according to the pathological results and immunohistochemical results, appropriate radiotherapy, chemotherapy and targeted drugs can be selected, including gemcitabine and pazopanib, which have certain therapeutic effects on smooth muscle sarcoma. Traditional Chinese medicine can also be chosen for treatment, which also has certain effect. After the discovery of abdominal smooth muscle sarcoma, timely consultation and treatment in regular hospitals, early detection and early treatment, drugs should be applied under the guidance of doctors.