Small rashes on the feet of leukemia belong to the skin damage manifestation of leukemia, the treatment can not only focus on the skin damage treatment, but also for leukemia for comprehensive and systematic treatment. The main means of treatment is systematic drug therapy. The main drugs are non-steroidal anti-inflammatory drugs, such as ibuprofen, celecoxib, etc., which can be antipyretic and anti-inflammatory; colchicine, which can inhibit granulocyte chemotaxis and control arthropathy, erythema nodosum, etc.; glucocorticosteroids, such as dexamethasone, which are mainly used for the acute onset of the lesions; and immune-suppressing agents, such as cyclophosphamide, cyclosporine, etc., which can play a role in anti-inflammatory and immune regulation. Small rashes on the feet of leukosis, it is recommended to seek timely medical attention, all drugs should be used under the guidance of a professional doctor.