The fastest treatment for bleeding stool should be based on the cause of the patient’s illness and condition, choose the most suitable treatment in order to achieve the fastest therapeutic effect; the common causes of bleeding stool, mainly digestive system diseases and blood system diseases, the specific treatment methods are as follows. 1. Digestive system diseases: (1) The treatments for ruptured variceal bleeding of esophagogastric fundus mainly include medication, endoscopic hemostatic therapy, interventional therapy and surgery. (2) Gastrointestinal tumors such as common gastric cancer, colorectal cancer, etc. The treatments mainly include surgical resection (radical surgery, etc.), radiotherapy (oxaliplatin and capecitabine, etc.), and targeted therapy (trastuzumab, etc.). (3) The treatment of hemorrhoids mainly includes general treatment (change of diet, etc.), drug treatment (magnesium hydroxide, sorbitol, etc.), and surgical treatment (hemorrhoidal simple excision, etc.). (4) The treatment of anal fissure mainly includes general treatment (adjusting diet, changing defecation habits, etc.), medication (oxybutynin gel, etc.), and surgery (anal fissure resection, etc.). 2. Blood system diseases: ① the treatment of thrombocytopenia is mainly to remove the cause of treatment and platelet transfusion supportive therapy. ② Leukemia treatment includes chemotherapy, targeting, immunotherapy and hematopoietic stem cell transplantation. ③The treatment of disseminated intravascular coagulation mainly includes the treatment of underlying diseases, the application of blood products and the application of heparin. If the patient has bleeding in the stool, he should go to the hospital in time to determine the cause of the disease, follow the doctor’s instructions for standardized treatment, and should not blindly use the drugs on his own. All of the above drugs should be used under the guidance of a doctor.