If duodenal ulcer is found in gastroscopy, it can be treated by lifestyle improvement, medication, endoscopic treatment or surgery. 1. Improvement of lifestyle: first of all, we should pay attention to rest, regular diet, avoid spicy, cold and other stimulating foods, stop using unnecessary non-steroidal anti-inflammatory drugs, avoid stressful emotions, quit smoking and drinking. 2. Drug therapy: including acid inhibitors, antacids and mucosal protectants, acid inhibitors include omeprazole, rabeprazole, ranitidine, famotidine, etc., and mucosal protectants include misoprostol, colloidal bismuth, aluminum thioglycollate gel and so on. In addition, eradication therapy should be performed in patients with co-infection with Helicobacter pylori. The classic four-drug eradication program is usually used. 3. In case of ulcer-related complications, such as perforation, hemorrhage, pyloric obstruction, endoscopic treatment should be preferred, and surgical treatment can be chosen for patients who are ineffective in endoscopic treatment. All of the above drugs are contraindicated in case of allergy and all should be taken in accordance with medical advice. If the patient is diagnosed with duodenal ulcer, it is recommended to go to the regular hospital in time, under the guidance of the doctor to carry out targeted treatment, in order to reduce the adverse effects of the disease.