The following drugs are available for apical inflammation: 1. Nitroimidazoles are drugs for the treatment of anaerobic bacterial infections and can effectively kill Porphyromonas gingivalis, Prevotella intermedia, Clostridium nucleatum, and spirochetes present in the apical region, which are very effective for the control of acute symptoms of periapical inflammation. 2. Tetracyclines can inhibit a variety of pathogenic bacteria and facilitate the repair of alveolar bone. 3. Penicillins have a strong bactericidal effect 4.Macrolides have high drug concentrations in the gums and jawbone, and have a strong inhibitory effect on Gram-positive and negative bacteria.