Blurred consciousness in the late stage of cholangiocarcinoma may be caused by the tumor metastasis compressing the brain nerves leading to the consciousness disorder. Blurred consciousness in late stage of cholangiocarcinoma may be caused by tumor metastasis compressing the brain nerves. It needs timely radiotherapy, and then take traditional Chinese medicine for auxiliary treatment, which can effectively control the metastasis of cancer cells, reduce some pains of patients and improve the quality of survival. Generally, there will be severe pain in the body during this period, and painkillers can be used appropriately. In addition, we must pay attention to strengthen the basic nursing care, because the patients with advanced cancer have lost the ability to take care of themselves due to blurred consciousness, therefore, we must pay attention to do a good job in patients’ oral care, skin care, urogenital care and so on, to create a more comfortable and quiet environment for the patients.