Positive rheumatoid factor is mostly considered to be related to rheumatoid arthritis, systemic lupus erythematosus, mononucleosis and other diseases, it is recommended to consult a doctor in time, under the guidance of the doctor to improve the relevant examinations to clarify the diagnosis, if diagnosed with the above diseases can be prescribed medication or surgical treatment. 1. Taking medication: (1) Rheumatoid arthritis: patients with this disease can usually see positive rheumatoid factor when they go to the doctor’s office for examination, and if they have joint pain, they can take non-steroidal anti-inflammatory drugs such as ibuprofen and diclofenac sodium, and anti-rheumatism drugs such as methotrexate, lancets, and etanercept, etc. as directed by the doctor. (2) Systemic lupus erythematosus: patients with systemic lupus erythematosus can also be seen as positive for rheumatoid factor, and can usually be treated with glucocorticosteroids such as methylprednisolone and prednisone, and immunosuppressive drugs such as methotrexate and merti-methacrylate as prescribed by doctors. (3) Mononucleosis: this disease can also cause patients with positive rheumatoid factor. Since the disease can be cured by itself, symptomatic treatment is mainly adopted, and those with fever can take ibuprofen, acetaminophen and other antipyretic drugs as prescribed by the doctor. 2. Surgery: Rheumatoid arthritis can be treated by joint replacement and other surgeries if it causes joint deformity. When the condition of SLE patients is serious, plasma replacement can be used for treatment. In addition, dry syndrome, dermatomyositis, influenza, bacterial endocarditis, etc. can also cause positive rheumatoid factor, it is recommended that the patient seek medical advice in a timely manner, and comply with the doctor’s instructions to complete the relevant tests to clarify the diagnosis and standardize the treatment.