Toothache can be rinsed with a mouthwash formulated with metronidazole, which can act as an anti-anaerobic bacteria. It is a drug designed mainly for gingivitis or pericoronitis of wisdom teeth, and is not effective for the more intense pain of acute pulpitis. Because the pain of acute pulpitis is a closed pain, it is necessary to go to the stomatology department for pulp drainage, which can instantly relieve the patient’s severe pain. Toothache needs timely clarification of the cause, just rely on mouthwash to relieve pain, just treat the symptoms not the root cause, it is recommended that patients, no matter what the cause of the toothache, should go to the stomatology department as soon as possible, so that the doctor for the patient to make a clear diagnosis, and symptomatic treatment, the patient’s teeth will gradually eradicate the pain, local use of mouthwash may have little effect.