Large teeth pain on both sides is mostly related to caries, gingivitis, periodontitis and other factors, and it is recommended that targeted treatment be carried out under the judgment of the doctor. 1. Dental caries: If the patient has dental caries, when consuming cold, hot, sour, sweet and other stimulating foods, it may invade the patient’s dental nerve, thus inducing pain. To brush teeth in a healthy way, fluoride treatment can be used as prescribed by the doctor, and filling of dental tissues is necessary. 2. Gingivitis: patients with gingivitis due to unhygienic oral conditions, which may lead to localized swelling and pain in the gums. It is recommended that these people pay attention to oral hygiene and take anti-inflammatory drugs if necessary. 3. Periodontitis: Periodontitis will appear in the late periodontal abscess, periodontal abscess acute stage will lead to gum pain or tooth pain. It is recommended that such people seek medical treatment in a timely manner, and follow the doctor’s instructions for targeted application of antibiotic treatment. If the patient appeared on both sides of the big toothache, it is recommended to go to the hospital in a timely manner, to clarify the cause of the disease and carry out the correct treatment.