Altered myelogram is a phenomenon that refers to changes in the degree of bone marrow cell proliferation, bone marrow cell count, granulocyte-red ratio, and the ratio of hematopoietic cells in each system and stage. Different types of bone marrow alterations have different etiologies. For example, iron deficiency anemia is mainly due to iron deficiency, but it is more or less related to the environment, such as radiation, etc. In megaloblastic anemia, the cause of megaloblastic anemia is folic acid or vitamin B12 deficiency. In aplastic anemia, myeloid changes are due to centripetal damage of the bone marrow and the development of compensatory hematopoietic foci. The bone marrow picture of SLE patients is found to be altered because most of the anemia is due to disorders of iron metabolism in chronic disease, and the anemia decreases with improvement of the primary disease; some of them are iron deficiency, and hemolytic anemia is rare; the bone marrow granulocyte proliferation pool and storage pool are normal; the rod nuclei are significantly more than the lobulated nuclei, with an average of 2.7:1; the bone marrow lymphocyte ratio is normal; the megakaryocyte classification results are similar to those of chronic ITP. The hemocytopenia was not mainly due to suppression of bone marrow hematopoietic function but to excessive destruction of peripheral blood cells.