Glycobiliary acid, an index generally used for the diagnosis of liver diseases, can be significantly elevated in acute hepatitis, chronic active hepatitis, cirrhosis, primary liver cancer and other diseases with high specificity after hepatocellular injury. In addition gallstone disease and intrahepatic bile duct stasis can also lead to elevated glycocholic acid. common disease factors are as follows: 1. liver cancer, glycocholic acid is significantly higher than normal in patients with liver cancer, and according to statistics, liver cancer rarely occurs in chronic hepatobiliary diseases with normal glycocholic acid. 2. hepatitis, decreased ability to take up glycocholic acid when hepatocyte function is impaired leads to elevated indicators, and can also be used as one of the indicators for clinical treatment and judgment of prognosis. 3, Intrahepatic bile duct stasis during pregnancy, usually elevated to more than 12 ml/L or 10-100 times the normal value, which can return to normal in 5-8 weeks after delivery.4. Cirrhosis, the degree of elevated glycolic acid and the development of cirrhosis are positively correlated.