There is no so-called fastest treatment for restless legs syndrome, the specific efficacy depends on different patients, mainly based on drug treatment. Most patients with primary restless legs syndrome have a family genetic history. They can be treated with dopamine drugs, such as dopamine agonists, commonly used are pramipexole, which is suitable for short-term treatment of moderate and severe patients. To avoid adverse effects such as nausea and drowsiness, they should be used under medical supervision. Patients with secondary restless legs syndrome should focus on treating the primary disease. If it is caused by iron deficiency anemia, iron supplements should be taken. Patients with restless legs syndrome caused by diabetes should pay attention to controlling blood sugar. Patients with folic acid deficiency should take folic acid supplements. Patients with restless legs syndrome are advised to consult a doctor in time to clarify the cause of the disease and then target treatment, do not blindly self-medication.