After the heel rubs out the blisters can be treated with alcohol cleaning and antibiotics, usually pay attention to wearing loose shoes, do not release the liquid, let it slowly fade to a certain extent, and then release the liquid if necessary, need to be disinfected with iodine volts, do not wrap fixed. When the liquid is released, use iodophor to scrub and disinfect three times, then use a sterilized needle to puncture the blister and squeeze out the exudate, then apply erythromycin ointment or Bactrim cream to protect the wound, and wear soft cloth shoes, take anti-inflammatory drugs, smear anti-inflammatory ointment, and usually eat less spicy food. It is recommended to avoid contact with water after the heel blisters are rubbed to avoid infection, avoid picking and scratching, and it is best not to break the blisters, which will dry up and recede on their own with better recovery and shorter recovery time. If the blister has ruptured, it is best to keep the wall of the blister, which can play a role in protecting the trauma. Topical application of recombinant human epidermal growth factor gel with fusidic acid cream and Bactrim cream can promote rapid epidermal growth while fighting infection, which is conducive to wound healing. It is recommended to wear loose, soft and comfortable shoes to avoid re-friction and aggravate skin damage.