Whether or not splenomegaly with high white blood cell count can be treated well depends on the cause of the disease. For example, splenomegaly with high white blood cell count caused by infectious diseases can usually be treated well; while leukemia, lymphoma and other blood diseases are more difficult to be treated well. Infectious diseases causing splenomegaly and high white blood cell counts are commonly caused by rubella virus infection and schistosomiasis, etc., which can usually be better recovered through antiviral treatment, deworming treatment and symptomatic treatment. Blood diseases such as leukemia and lymphoma can also cause splenomegaly with high white blood cell count. Some of the patients with leukemia and lymphoma may achieve clinical remission through radiotherapy, chemotherapy and hematopoietic stem cell transplantation, while some of them cannot be cured. Splenomegaly with high white blood cell count may also have other causes, such as cirrhosis combined with infection, etc. It is recommended to go to the hospital in time, whether and how to treat it can be judged and treated by professional doctors.