High thyroid peroxidase antibodies do not require special management, and only in combination with abnormal thyroid function do you need to intervene for thyroid function. If hypothyroidism is present, oral levothyroxine sodium can be used. Thyroid peroxidase antibody is a relevant indicator of autoimmune thyroid disease, and management measures need to be decided according to the results of thyroid function. 1. Simple high thyroid peroxidase antibodies: when simple high thyroid peroxidase antibodies are present but normal thyroid function, no special treatment is needed, only regular checkups are needed. 2. High thyroid peroxidase antibody combined with abnormal thyroid function: it can be divided into hyperthyroidism and hypothyroidism; in the case of hyperthyroidism, the cause of hyperthyroidism can be considered as graves’ disease, and then it is necessary to combine with the laboratory condition to actively anti-hyperthyroidism treatment; in the case of hypothyroidism, the cause of hyperthyroidism can be considered as Hashimoto’s thyroiditis, and it should be combined with the laboratory condition to carry out the levothyroxine replacement therapy. Therefore, high thyroid peroxidase antibody usually does not require special treatment, but if combined with abnormal thyroid function, it is necessary to be treated under the guidance of the doctor according to the specific test results and regular review.