Generally newborns total bile acid more than the normal value of 12 μmol / L is an abnormal phenomenon, due to the hospital testing instruments are different, may be slightly fluctuating, the specific normal value should be based on the hospital more to provide for diagnosis. Total bile acid refers to bile acid, goose deoxycholic acid, deoxycholic acid, lithocholic acid, ursodeoxycholic acid, etc., which can reflect the normal function of the liver well, and the normal value should be 0-12 μmol/L. Different hospitals may have different normal value ranges. When the normal value is exceeded, it may be due to acute or chronic severe hepatitis, congenital biliary atresia, congenital biliary dilatation, which is very harmful to the newborns and needs timely treatment. Newborns with elevated total bile acids need to consult a doctor in a timely manner, under the guidance of the doctor’s treatment, while paying attention to the newborn’s diet and hygiene, pay attention to warmth, to avoid being cold.